When to Pause Your Biologic Treatment: Expert Guidance from Carol Marston, Lead Nurse – Biologics

Biologic therapies have transformed the management of chronic conditions, offering relief to many patients. However, there are certain situations where it might not be advisable to continue your biologic injections. It’s important to remember that you should never stop your treatment without first consulting your specialist team. Doing so could leave you vulnerable to a relapse or a recurrence of your symptoms. Your clinical team is there to provide you with tailored advice and guide you through any necessary adjustments to your treatment plan.

Here are some key scenarios where you should reach out to your specialist team for advice:

Prolonged Illness

Biologics work by suppressing your immune system to prevent the inflammatory responses that cause your symptoms. However, this suppression can also hinder your body’s ability to fight off infections. If you experience a prolonged period of illness, your specialist may recommend temporarily halting your biologic therapy to allow your immune system to recover and combat the infection. Your clinical team will help determine the best course of action for your situation.

Vaccinations

There is evidence suggesting that biologics may reduce your immune response to vaccines. Vaccines are designed to teach your immune system how to fight off specific germs and the diseases they cause. If you are due to receive a vaccine, especially a ‘live’ vaccine, it is important to consult with your specialist team. Live vaccines contain a weakened form of the germ that causes the disease, and because biologics suppress your immune system, you may be at higher risk if exposed to these live agents. Your clinical team will guide you on how long to pause your biologic treatment before and after receiving the vaccine.

Upcoming Surgery

Biologics can increase the risk of infection post-surgery due to their immune-suppressing effects. Your clinical team will assess the risk of infection against the potential for a flare-up of your condition. Typically, they may advise you to stop your biologic injections a few weeks before your surgery to ensure your immune system is better equipped to heal. After your surgery, once healing has occurred and you feel well enough, your team will guide you on when to resume your treatment.

Pregnancy or Conception

If you are pregnant or trying to conceive, it is essential to have a conversation with your clinical team. While pregnancy is not necessarily a reason to stop biologic treatment, your team will help you evaluate the benefits and potential risks. They may recommend switching to an alternative biologic or adjusting your treatment plan to support both your health and that of your baby.

Experiencing Side Effects

If you develop new side effects or notice that existing side effects are worsening, it is important to contact your clinical team. There are various biologics available, and your team may recommend switching to a different one that is better suited to your needs.

Active Infection Requiring Antibiotics

If you need to take antibiotics for an active infection, it is advisable to consult your clinical team. They will provide guidance on whether you should pause your biologic treatment and for how long.

Always Refer to Your Patient Information Leaflet

For general advice, you can refer to the Patient Information Leaflet that comes with your medication. However, for any uncertainties about continuing your biologic therapy, it is always best to contact your medical team. They are available to discuss your individual circumstances and offer tailored advice to ensure the best outcomes for your health.